Required skills Conceive, develop and implement patient IPSCderived 3D culture models of ALS, SETD5 and SHANK3 diseases for drug discovery; design, set up and conduct phenotypic screenings in cortical and motoneuron 3D brain models to identify novel medicines; develop, optimize and run drug discovery automation platforms by combination of FLIPR, high content imaging and cell morphology analysis; screen, optimize and validate gene therapy vectors in human 2D and 3D human in vitro disease models of neurodegeneration and developmental encephalopathies; 10 years of experience in human disease modeling in the pharmaceutical industry. Requires travel up to 10 of the time.

Categories: eb3

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